Premature and early menopause: risk factors is Jordanian women

To identify risk factors associated with the onset of premature [<40 years] and early [40-45 years] menopause in a sample of Jordanian women. This prospective study was undertaken at Princess Aisha Medical Complex, Amman between August 2007 and February 2008. A total of 1,000 postmenopausal women were included. Factors taken into consideration were age at menarche, age at first delivery, parity, number of miscarriages, history of gynaecological or obstetric surgeries [ovarian, tubal and /or uterine], smoking status and history of premature menopause in first-degree relatives. Out of the 1,000 women, 129 [12.9%] had had menopause before the age of 46 years: 27 [2.7%] before the age of 40 and 102 [10.2%] before the age of 46 years. In these groups, the only statistically significant factor was history of premature menopause in fist-degree relatives. Interestingly, in women who had had menopause after the age of >/= 46 years, the rate of hysterectomies was statistically higher. Early and premature menopause is strongly associated with history of premature menopause first-degree relatives. No other factors studied proved to have any statistical significance

Clinical-pathological feature of primary endometrial cancer patients treated with hysterectomy at King Hussein medical center

To describe the clinical and histopathological features of patients with primary endometrial cancer operated at King Hussein Medical Center the last six years. This retrospective study included cases operated in at King Hussein Medical Center in the period between October 2001 and December 2007. Histopathological data were available for 78 females: however, only 52 patients with primary endometrial cancer were included in this study. Patients with endometrial cancer who were diagnosed after hysteroscopy and endometrial biopsy, and those who had secondary endometrial cancer were excluded from this study. Clinical and histopathological details were collected and analyzed. The sample consisted of 52 females. Age ranged from 14 - 78 years [mean 59.00 +/- 13.35]. The most common presenting symptom was postmenopausal bleeding which occurred in 37 patients [71.2%]. Endometrioid Adenocarcinoma was the predominant histological sub-type, being reported in 34 patients [65.4%], while other types including mixed Mullerian tumors, endometrial stromal sarcoma, clear cell carcinoma, adenosquamous carcinoma, adenocanthoma and papillary serous adenocarcinoma were found among 18 patients [34.6%]. The tumor was confined to the body of the uterus [Stage one] in 30 specimens [57.7%] at the time of surgery. Endometrioid adenocarcinoma of the endometrium is the most common primary endometrial carcinoma operated upon at King Hussein Medical Center. Postmenopausal bleeding was the predominant presenting symptom. Most of the patients were diagnosed early